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Discussion The main findings of this study include: (i) higher CAT activity and its relative mRNA levels in the kidneys of SHR from the age of 2 weeks (Figure 2 and Table 2), (ii) lower kidney GPx activity in SHR from the age of 3 weeks and lower relative GPx mRNA levels at 8 and 10 weeks of age (Figure 3 and Table 2), (iii) higher renal TAS in SHR from the age of 3 weeks and onward (Table 3), (iv) higher renal MDA levels at 16 weeks (Table 3), (v) lower levels of renal H 2 O 2 in SHR from the age of 8 weeks (Table 4) and (vi) no significant difference in renal total SOD activity or the relative SOD mRNA levels of CuZn-SOD and Mn-SOD (Figure 1 and Table 2) when compared with age-matched WKY rats

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FGF21 interacts with SIRT1 to promote fatty acid oxidation, improve insulin sensitivity, and reduce hepatic inflammation, supporting metabolic regulation