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Hence, there is a great need for more innovative drugs as well as treatment approaches that offer improved target selectivity and are amenable to localized delivery, particularly to small joints, to ultimately enhance therapeutic outcomes in patients with RA

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However, metabolic tracing of 13 C-heptanoate indicates that propionyl-CoA predominantly produces glutamine, which indicates that astrocytic metabolism is responsible for the majority of this anaplerotic pathway (Marin-Valencia et al., 2013)