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3 Ferroptosis and non-immune modulation 3.1 RPE cells Serving as a monolayer of pigmented cells between the neurosensory retina and the choriocapillaris, RPE maintains subretinal homeostasis by performing multifaceted functions, including forming the blood-retinal barrier (BRB), transporting nutrients and growth factors, and phagocytosing PR outer segments (79)

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Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

AOD 9604 best clinical result was approximately 2.8kg of additional fat loss over 12 weeks, and the larger confirmatory trial (OPTIONS study, 536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo