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Some patients experience persistent nausea, vomiting, or constipation on tirzepatide that either doesn't improve with time or becomes incompatible with daily life
A new and unused Ozempic pen should immediately go in the fridge
Furthermore, its tolerability profile, which includes weight gain, edema/fluid retention, fractures, and (rarely) bladder cancer in long-term use, could hinder its potential repositioning for depression [173]
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