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And in the STEP trials, patient-reported physical functioning improved more on the drug than on placebo (STEP patient-reported outcomes, 2024), because unloading forty pounds of fat does more for how a body moves than a modest dip in muscle takes away
In these patients, the signature 11 mutation loads in metastatic disease were coincident with predicted deleterious mutations in DNA-mismatch repair genes, including MSH6 (CAS-G and SK-H), MLH1 (CAS-G), MLH3 (CAS-G and SK-H) and MSH3 (SK-H)
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The dual action also promotes weight loss by reducing appetite and increasing feelings of fullness, which is particularly beneficial for many type 2 diabetes patients who struggle with obesity
28 They found that GLP-1 RA use was associated with a lower risk of incident glaucoma (hazard ratio [HR] = .81), with the risk decreasing even further when GLP-1 RAs were used for longer than 3 years (HR = .71)
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