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Clinical trial data suggests tirzepatide produces greater average weight loss than semaglutide, largely because it activates both the GLP-1 and GIP receptors rather than just GLP-1
These symptoms are primarily due to the mode of action of GLP-1 RAs on the gut, as a GLP-1 may directly or indirectly regulate electrolyte and fluid homeostasis by influencing feeding and drinking behavior as well as electrolyte transport in the kidneys and gastrointestinal tract [25]
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