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Mice were monitored for survival over a 7-day period
Pregnenolone A precursor for progesterone, allopregnanolone, DHEA and other steroids
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Typically dosed daily at night to align with the bodys natural nocturnal GH release
Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations
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