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This phenomenon is explained by the BurtonIngold hypothesis, whereby -carotene shifts from an antioxidant to a pro-oxidant under high oxygen tension, as found in the pulmonary environment of smokers
Weeks 12: Your body is beginning to replenish its cellular stores
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
(2012) 129:e2516
All three studies appear in Alternative Therapies in Health and Medicine, a journal that does not carry the same peer review rigor as major medical journals
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