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Dehydration and acute kidney injury risk is elevated with persistent gastrointestinal losses, particularly in older adults or those taking diuretics or RAAS-blocking medicines

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The experimental drug also appeared to be safe and tolerable, with adverse events similar to other GLP-1 drugs (mostly gastrointestinal and mostly mild to moderate in severity)

Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review

Mast cell degranulation also floods the system with histamine that must be conjugated (both N-methylated by HNMT intracellularly and oxidized by DAO extracellularly)