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Similarly, in macrophages, classical activation of pro-inflammatory M1 macrophages promotes glycolysis to support antimicrobial function and cytokine production, while anti-inflammatory M2 macrophages primarily utilize OXPHOS and FAO for tissue repair and homeostasis (52, 53)

CAVER default parameters were specified for the tunneling algorithm, using 12 approximating balls with minimum probe radius of 1.5, shell depth of 20, shell radius of 7 (or 10 for structures where a smaller radius fails to fill the tunnel space), and a clustering threshold of 3.5