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GLP-1R-deficient mice exhibit learning disabilities, and this can be reversed by introducing the GLP-1R gene into the hippocampus
The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]
Phentermine commonly causes insomnia and restlessness due to its stimulant properties, while tirzepatide commonly causes fatigue and low energy, particularly during dose escalation
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