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Ann.Indian Acad.Neurol
Miras AD, Prez-Pevida B, Aldhwayan M, Kamocka A, McGlone ER, Al-Najim W, et al
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Attributed to the selective IR paradox, compensatory hyperinsulinemia can amplify hyperandrogenism via several mechanisms: (i) cross-activation of insulin and/or IGF-1 receptors, which enhances LH-mediated expression of key steroidogenic enzymes (e.g., CYP17A1) in ovarian theca cells and increases androgen synthesis
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