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We have eagerly awaited seeing the actual results since the sponsor company (Novo Nordisk) issued a press release in August that proclaimed a 20% relative reduction of cardiovascular death, heart attack or stroke, the primary endpoint of the trial
control group
(Arumugasaamy et al., 2019) found that both fluoxetine and sertraline slowed calcium oscillations in cardiomyocytes, inducing the increased secretion of troponin T and creatine kinase-MB, while also decreasing the secretion of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), all three of which are key biomarkers of cardiac injury
Additionally, 15% of flagged ads offer the medication entirely without prescription requirements, raising concerns about the authenticity and safety of those drugs
Individual visual inspection of docking results allowed the selection of hits that dock into each binding site, G-site and H-site, and show favorable binding interactions (Supplementary Table S4)
