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Tirzepatide acts on two hormone receptors (GLP-1 and GIP) while semaglutide acts on one
Tirzepatide has shown greater efficacy than semaglutide due to its dual action on glucagon-like peptide-1 and glucose-dependent insulinotropic peptide receptors
Treatment recommendations depend on your individual goals and clinical review
Tirzepatide itself can cause fatigue , particularly during dose escalation and in the early weeks of treatment
Talking to a healthcare provider before starting both medications ensures that you receive the best guidance for your specific situation
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