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, -1 - Very comprehensive and up-to-date editorial just published in Metabolism It includes: overall summary semaglutide programme Mechanisms of actions of semaglutide in patients with MASLD and MASH Results from trials in MASH and MAFLD including the interim results from 800 patients involved in part 1 of the ESSENCE trial were published Summary of other GIT hormone-based therapies under the development Really interesting story and quite nice efficacy despite the fact that there are no GLP-1 receprors (or GIP receptors for that matter) in the liver Now the next step is to improve screening of our patients for MASH And also to agree on the combination of non-invasive tests to replace liver biopsy Awesome
Baseline co-morbidities The TRIUMPH-4 population had obesity plus knee osteoarthritis
Once-weekly dosing therefore produces sustained drug concentrations that are an order of magnitude or more above physiologic baseline
In SUSTAIN 6, subjects with T2D at high CV risk treated with semaglutide had a 26% lower risk of the primary composite outcome of first MACE (death from CV causes, nonfatal MI, or nonfatal stroke) vs those receiving placebo over 2 years (p = 0.02 for superiority [post hoc]) [12]
Undermethylation: Genetic Predisposition or Environmental Depletion of Methyl Compounds
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