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[1] If side effects significantly impair your quality of life despite timing adjustments, your prescriber may consider dose modification or alternative treatment options

Treatment guidelines do not give a definite upper limit for basal insulin dose, and there may be the temptation to continue with a familiar routine by increasing the basal insulin dose despite the patient still not achieving glycemic targetsa situation known as over-basalization [10]

We can deduce from the figure above that 32.2% of the semaglutide group lost less than 5% of their body weight, while 22.9% lost more than 15% of their body weight a decent amount of variation