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Visceral fat and IGF-1 are meaningful measures, but they are surrogate/intermediate endpoints, not hard clinical outcomes like cardiovascular events

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58 SellHRohrbornDIndrakusumaIJelenikTCastanedaTRAl-HasaniHet alAdipose-specific dipeptidyl peptidase 4 (DPP4) knockout mice display improved fasting insulin and cholesterol levels despite increased weight gain on HFD

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Weight is determined primarily by biology and genetics, not by willpower alone. But taking anti-obesity medications isnt the easy way out, said Rekha B

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