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Local injection site reactions are the most common and typically include: Erythema (redness) and warmth at the injection site Swelling or induration (hardening of tissue) Pruritus (itching) or discomfort Bruising or nodule formation in some cases (particularly with exenatide extended-release formulations, where nodules are common and often non-allergic) These reactions usually appear within hours of injection and may resolve spontaneously within a few days
It is related to a deficiency of the vitamins B12 and B6
Nat Metab 2025;7:1282-1298 Erratum in: Nat Metab 2025;7:1299
These changes support healthier cell function and may help ease some of the slow biological wear that contributes to aging
They use the same active pharmaceutical ingredient as the branded product - semaglutide or tirzepatide - but they are fundamentally different in regulatory status
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