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Research on contestants from The Biggest Loser showed metabolic suppression lasting at least six years after their weight loss

GLP-1 receptor agonists reduce alcohol intake: Evidence from preclinical and clinical studies

Extended 15-year follow-up studies showed that treatment prevented age-related impairment of physical endurance, normalized circadian rhythm of melatonin production, and improved carbohydrate and lipid metabolism markers

However, as the futility boundary was crossed, there is enough data to exclude the association between GLP-1 agonists treatment and pancreatic cancer (considering a difference of 0.1% between treatment groups) (Fig