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NLRP3 inhibitor Oridonin can suppress the expression of IL-18 and IL-1, alleviate inflammation, preserve myocardial function and improve myocardial remodeling by reducing NLRP3 expression [89]

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GRd is a homodimer with one flavine adenine dinucleotide (FAD) in each subunit [102, 103]

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Each offers unique benefits and comes with its share of side effects