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10.3389/fcvm.2019.00153 123 MetzelaarM
1.2 The physiology of incretins GIP (the one which provides the most of incretin effect in humans (7)) and GLP-1, are peptide hormones secreted respectively, L cells of the bowel and K cells of duodenum after assumption of carbohydrates, triglycerides, proteins or amino acids (44, 45)
This leads to higher blood sugar and further promotes fat storage leading to conditions like insulin resistance
Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice
Long-Term Effectiveness Studies show that weight loss with semaglutide is sustainable
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