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If these four areas have been addressed and the patient is genuinely stalled at an appropriate dose, with adequate protein, with strength training in place, and with honest tracking confirming the deficit, then the conversation about adjunct therapy becomes meaningful

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Missing data for the trial product estimand were handled through multiple imputation using the Markov Chain Monte Carlo method, assuming that non-adherent participants would have responded similarly to adherent participants within the same treatment arm

But for this metabolic factory to run smoothly, it needs two things: machinery and a crew to operate it

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