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The treatment must be an add-on therapy to optimal standard treatment, which must include, unless contraindicated or cannot be tolerated, a beta blocker and angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker or angiotensin receptor-neprilysin inhibitor
translation to another tissue, species, or route of exposure
Participants receive a single administration of the investigational drug, starting from a low dose level derived from preclinical evidence and set as the MRSD
Es decir, ambas hormonas trabajando juntas logran mayores beneficios que por separado
This suggests that the GABAergic innervation of the PVN may originate from the LH, which, in turn, receives projections from the AON, as shown in our study with CTB retrograde tracing from the LH
