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10.1042/bj3010649 Biochem J
(A few other, less-invested experts from the FDA were added to the panel after pushback before last weeks meeting
In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins