In conclusion, this trial demonstrates the superiority of oral semaglutide vs sitagliptin in reducing HbA 1c and body weight from baseline in a predominantly Chinese population with type 2 diabetes, as well as a safety and tolerability profile for semaglutide that is consistent with that of the GLP-1RA class
AiyerAVisserSByePBrittonWWhiteleyGGlasbeyTet al
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Alterations to the peptide structure, specifically at the 2nd, 8th, 15th, and 27th amino acid positions, are thought to potentially improve the peptide's stability against breakdown by the enzyme dipeptidyl peptidase-4
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