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Nearly a century ago, Warburg observed that cancer cells can convert glucose into lactate even when oxygen is available, a phenomenon termed aerobic glycolysis or the Warburg effect (Liberti et al., 2016)
While skin biopsy is unparalleled for small-fiber evaluation, current guidelines recommend integrating it with nerve conduction studies and clinical examination for comprehensive neuropathy assessment [41]
Doses of sitagliptin up to 125 mg/kg (approximately 12 times the human exposure at the maximum recommended human dose) did not impair fertility or harm the fetus
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