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Both effects are well established for native amylin and for pramlintide, and are the pharmacological basis of pramlintides approved use as an insulin adjunct [2]
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CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH), a 29-amino-acid peptide modified with a Drug Affinity Complex (DAC) that extends its biological half-life from minutes to several days
The schedule should answer the study question
The same is true for bariatric surgery, currently the most effective intervention for obesity, which can also drive type 2 diabetes into remission
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