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The molecular basis for this selectivity difference is not fully characterized at the structural level but is attributed to ipamorelin's distinct binding mode at the receptor's orthosteric site, which appears to bias the downstream signaling cascade toward the GH-releasing pathway rather than the full spectrum of ghrelin receptor activity
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Neural progenitor cells used in this study were derived from the WA09 human ESC line (H9 ESC) derived by Dr James Thomson and distributed by WiCell Research Institute under SLA agreement
