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This is not necessarily alarming, but it represents a real gap in knowledge

This table from a 2025 meta-analysis shows the average weight change compared to a control group after stopping anti-obesity medications

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Histamine H 3 Antagonists/Inverse Agonists A number of recent studies have suggested that histamine affects food and water consumption by acting on the central nervous system receptors (67)

It is currently available as an injection and an oral pill