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Cimino JA et al

It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals

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Biochemistry of type 1 diabetes: from metabolic dysfunction to cellular stress Disorders of glucose and insulin metabolism The progressive destruction of pancreatic beta cells due to autoimmune attack is the first and most obvious biochemical disorder, which is the reduction or cessation of insulin secretion [78]