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Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids

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And we think that this is because of differences in the intrinsic efficacy of TAAR1. Talah Khoury, Slovensk akadmia vied / Slovak Academy of Sciences Our novel TAAR1/5-HT1AR dual agonist is a promising candidate for diseases characterized by psychosis and other neuropsychiatric symptoms. Masato Tanuma, Sumitomo Pharma Co., Ltd

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This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24