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The maintenance of normal structure and function of the cardio-cerebrovascular system requires a balance between the production and death of cells (including cardiomyocytes, endothelial cells, vascular smooth muscle cells, and neurons) in the tissues and organs (Zhaolin et al., 2019)

However, gastrointestinal side effects, including diarrhea, constipation, and abdominal discomfort, have been reported in approximately 35% of patients, especially during initial usage

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The above-mentioned functional roles of GSTF6 are in agreement with its first proposed biological function, which was to participate in defense mechanisms against pathogens (e.g., P