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2024 Jul;30(7):2037-48
We found that administering 80-nM GLP-1 significantly counteracted the inhibitory effect of pasireotide on high glucose (20 mM)-induced insulin production, aligning with the cAMP levels in GLP-1R-MIN-6 cells
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Purified DNA was denatured by heating and MeDIP and hMeDIP were conducted with 5mC or 5hmC antibodies as we previously described 64
Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, 15-mg tirzepatide doses and placebo, respectively [49]
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