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The Journal of Physiology, 592 (Pt 7), 1425-1426

In patients with overweight or obesity, the GLP-1 signaling system is often dysregulated: hunger feels constant, fullness feels temporary, and the underlying metabolic machinery is calibrated against weight loss

A review of the literature indicates that the 5-year survival rate within a broad range of 4.5-48%, but a large cluster occurs at 10-25%

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