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The therapeutic mechanism may be associated with accelerated granulation tissue formation, reepithelialization, dermal remodeling, and collagen deposition through ERK1/2 signaling pathway
Its contribution to bone healing is primarily systemic, focused on ensuring the right cells arrive quickly and that the resulting tissue is structurally sound [4, 6]
The authors research whether TB-500 may tone down this signaling and suggest that the peptide may increase the level of miR-146a, a small regulatory RNA molecule whose role may be to act as an internal brake on inflammatory signaling pathways
Tingling or numbness: Mild paresthesia in the extremities, related to fluid shifts and usually resolving within days
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