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Start with a moderate, consistent dose (e.g
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This study program named SURPASS comprises six global, two Japanese, and one Asian-Pacific study (69)
Mechanistically, silencing P2X4 blocks the NLRP3/caspase- 1 pathway, demonstrating a neuroprotective effect in an intracerebral hemorrhage mouse model, while administration of an NLRP3 activator induces neuronal impairment in the same model (Wu et al
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