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also identified as SCEH) gene
Yes, but fair skin requires longer loading (3 to 4 weeks instead of 1 to 2 weeks) and higher cumulative doses (20 to 50 mg instead of 5 to 10 mg)
However, these mechanisms are only part of the factors that affect skin tone
In the MAPK pathway, clinical evaluation includes agents such as LY3009120 (NCT02014116) and ulixertinib in combination with palbociclib (NCT03454035) for patients with advanced pancreatic and other refractory solid tumors
PMID 20981235
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