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Pre-clinical studies in genetically modified animal model of T2DM (OLETF rats, Otsuka Long Evans Tokushima fatty rats) have shown high PRA (plasmatic renin activity) levels, without any change in aldosterone levels under dapagliflozin chronic treatment, in accordance with the aforementioned observations of an independent intrarenal RAS (36)
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TRIUMPH had separate clinical trials: one in individuals with type-2 diabetes and obesity, and the other in non-diabetics with obesity and cardiovascular disease
Participants can also qualify if they have a BMI of 27 or higher along with an obesity-related condition, like cardiovascular or liver disease
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