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An eGFR just below 60 typically indicates the presence of early-stage CKD and is also associated with a significantly increased risk of cardiovascular and any-cause mortality, kidney failure, acute kidney injury, or the progression of CKD
This is also consistent with a higher PLCE1 gene expression in the normal colorectal tissues as compared to the colorectal adenocarcinoma in the Oncomine cancer microarray dataset (Figure 2D)
It's not a switch you flip
It was unregulated access without physician oversight, and that risk doesnt go away no matter what the regulatory status becomes
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