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Indeed, pioglitazone-induced heart failure (HF) and the withdrawal of rosiglitazone because of cardiovascular concerns eventually led to a change in the policy of regulatory authorities.9,10 The US Food and Drug Administration and the European Medicines Agency now require all new antidiabetic drugs to undergo large cardiovascular outcome trials (CVOTs) to confirm cardiovascular safety and benefits
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Therefore, the action of metformin on the gut endocrine system may be L cell-specific and, more precisely, GLP-1-specific
Hesitation or slow insertion typically increases discomfort
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