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Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers
In research models, it activates the GIP, GLP-1, and glucagon receptors simultaneously
At the same time, it tells the pancreas to make less glucagon, cutting down spikes in blood sugar
Importantly, a high percentage of semaglutide recipients achieved weight reductions of 5%, 10%, and 15%, showcasing the drugs potential for significant weight loss
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