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Over the past 35 years, Drucker has led the field in delineating the importance of GLP-1 action for the control of pancreatic beta cell proliferation and survival, regulation of endoplasmic reticulum (ER) stress, and beta cell plasticity

220 HIF-1 interacts with BCL2, BNIP3, BNIP3L/NIX, Beclin-1, ATG proteins, and PIK3C3 to stimulate autophagy, 221,222 while AMPK and PTEN suppress mTORC1, activating ULK1 and enhancing autophagosome-lysosome fusion

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Pay close attention to any changes in your body