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It produces worse side effects, more discontinuations, and often slower progress because severe GI symptoms prevent adequate nutrition and hydration
A: Not all patients are candidates
doi: 10.1016/j.molmet.2018.12.001 71 TurtonMDO'SheaDGunnIBeakSAEdwardsCMMeeranKet al
J., Prendergast, G., Howe, S
12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward
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