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Patients planning surgery should discuss tirzepatide with their healthcare team, though recent guidance from the American Society of Anesthesiologists indicates most patients can continue GLP-1 receptor agonists perioperatively, with modifications only for those at high risk of gastrointestinal complications

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References: GLP1 Receptor Agonists-Effects Beyond Obesity and Diabetes

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The question is no longer whether combining these therapies is biologically plausible

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