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These medications have changed the landscape
This table is not exhaustive but illustrates the scale: multiple deals approach or exceed the billion-dollar mark, and two (Pfizer/Metsera and Roche/Zealand) surpassed $5B
The cardiovascular benefit is most consistent for the long-acting agents (liraglutide, injectable and oral semaglutide, and dulaglutide), whereas exendin-based and shorter-acting agents (lixisenatide, once-weekly exenatide) were largely neutral on MACE in dedicated outcomes trials [25]
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