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Challenges in the pathophysiology, diagnosis, and management of intestinal fibrosis in inflammatory bowel disease

The disassembly of adhesion sites and the endocytosis of integrins require the disruption of the strong transmembrane linkage mediated by integrins between the actin cytoskeleton and the extracellular matrix

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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

Furthermore, recent findings reveal that alterations in BBB and its transporters affect the entry of therapeutic drugs designed to treat neurodegenerative diseases (Zhang, 2025)