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In a mouse model of UUO, treatment with finerenone (3 or 10 mg/kg) once daily starting with the first dose 2 days before UUO, decreased pathological myofibroblast accumulation and collagen deposition along with decreased expression of kidney fibrosis markers PAI-1 and naked cuticle 2 (NKD2) [197]
Longitudinal research refers to studies that follow participants over a long period of time to observe changes and developments
Chen L, Yang X, Zhang L, et al
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Current data suggest that the oral formulation leads to clinically meaningful weight loss, but on average, it appears less effective than higher doses of high-efficacy injectable GLP-1 therapies, says Jaime Almandoz, MD, medical director of UT Southwestern Medical Centers weight wellness program
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