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Some studies comparing tirzepatide and semaglutide over 72 weeks found that tirzepatide was more effective in reducing body weight and waist circumference
However, head-to-head clinical trials remain limited
Curr Opin Plant Biol 14:435443
For example, just 0.04% of people on semaglutide or tirzepatide developed NAION, compared with 0.02% of people on other diabetes medications
The recent December 2025 phase 3 trial showed even better results
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