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Physiological Reviews , 87(4), 14091439

This release is rapid, and is known to peak at around 10 min from the initial glucose challenge, whilst the second phase of insulin release, which is sustained, consists in the release of granules from the larger Reserve pool (RP), containing ~9599% of insulin granules, and lasts until glucose stimulation ends (3060 min under normal physiologic conditions) (16, 35)

Furthermore, classical apoptosis regulators like BCL-2 have been found to indirectly modulate cellular susceptibility to ferroptosis by influencing the mitochondrial voltage-dependent anion channel (VDAC) or directly interacting with proteins like GPX4, revealing interactions between these two death pathways at the organelle level

proposed a synergistic strategy that combines oxygen-enhanced sonodynamic therapy with ferroptosis via engineered exosomes, demonstrating higher efficacy in anticancer treatment [154]