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This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway

Tabe Y, Jin L, Ichikawa N, Konopleva M, Andreeff M , Miida T

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21 and 26 illustrated a substantial elevation in the expression of both VEGF and platelet endothelial cell adhesion molecule-1 (CD31) on day 7 after treatment with G/D-CuP, compared to the negative control and Gel groups